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学术预告:Novel laser-based technology for improved drug/vaccine delivery

  

报告题目:Novel laser-based technology for improved drug/vaccine delivery

报告人: Xinyuan Chen Ph D,

单位:哈佛医学院马萨诸塞州综合医院皮肤科韦尔曼光医学中心

时间:2015527日下午3:00

地点:南师大生科院3楼椭圆形会议室

欢迎参加。

受教育经历:

博士后 (2008-2012)  药物/疫苗运输      哈佛医学院马萨诸塞州综合医院

博士后 (2007-2008)   神经免疫学        伯克/康奈尔医学研究所

博士 (2006)     生物化学和分子生物学  南京大学分子医学研究所

本科 (2001)            生物化学        南京大学基础学科教学强化部

研究经历:

2012.2-至今 Instructor, 哈佛医学院马萨诸塞州综合医院皮肤科韦尔曼光医学中心

2008.3 – 2012.1 Research fellow, 哈佛医学院马萨诸塞州综合医院

2007.3 – 2008.3 Research fellow, 伯克/康奈尔医学研究所

2001.9 – 2006.6 Graduate student, 南京大学

2000.9 – 2001.6 Undergraduate research student, 南京大学

发表文章:

Upcoming manuscripts:

1. Zhou C, Chen X, Zhang Q, Wang J, Wu MX. Laser enhances the delivery and efficacy of malaria sporozoites vaccines. (manuscript preparation)

2. Chen X, Wu MX. Skin delivery with adjuvants to improve immunogenicity of nicotine vaccine. (Invited Book Chapter preparation)

3. Chen X*, Zhang N, Liu S, Wu MX. Fractioanl skin delivery to improve safety and immunogenicty of nicotine vaccine. (manuscript preparation) *, corresponding author

Peer reviewed publications:

4. Chen X*, Kositratna G, Zhou C, Manstein D, Wu MX. “Micro-fractional epidermal powder delivery for improved skin vaccination”. J Control Release, 2014 (in print) *, co-corresponding author

5. Wang J, Shah D, Chen X, Anderson RR, Wu MX. “Micro-sterile inflammation array as safe adjuvant for influenza vaccines”, Nature Communications. 2014, 5:4447 (in print).

6. Chen X, Wang J, Shah D, Wu MX. “An update on the use of laser technology in vaccine2 immunization”. Expert Rev Vaccines. 2013, 12 (11), 1313-1323.

7. Chen X, Wu MX. How effective could laser-based approaches be in assisting dendritic cell immunotherapy? Immunotherapy. 2012; 4(10):983-5.

8. Chen X, Pravetoni M, Bhayana B, Pentel PR, and Wu MX, High immunogenicity of nicotine vaccines obtained by intradermal delivery with safe adjuvants. Vaccine. 2012; 31(1):159-64.

9. Zhi L, Ustyugova IV, Chen X, Zhang Q, Wu MX. Enhanced Th17 Differentiation and Aggravated Arthritis in IEX-1-Deficient Mice by Mitochondrial Reactive Oxygen Species-Mediated Signaling. J Immunol. 2012; 189(4):1639-47.

10. Chen X, Zeng QY, Wu MX. Improved Efficacy of DC-based immunotherapy by cutaneous laser illumination. Clin Cancer Res. 2012; 18(8):2240-9.

11. Chen X, Shah D, Kositratna G, Manstein D, Anderson RR, and Wu MX, Facilitation of transcutaneous drug delivery and vaccine immunization by a safe laser technology, J Control Release. 2012;159(1):43-51.

12. Chen X, Wu MX. Laser vaccine adjuvants for cutaneous immunization. Expert Rev Vaccines. 2011, 10(10):1397-403.

13. Chen X, Kim P, Farinelli B, Doukas A, Yun SH, Gelfand JA, Anderson RR, Wu MX. A Novel Laser Vaccine Adjuvant Increases the Motility of Skin Antigen Presenting Cells. 2010; PLOS one. 5(10):e13776.

14. Shahid M, Shen L, Seldin DC, Lu B, Ustyugova IV, Chen X, Zapol WM, Wu MX. Impaired 3',5'-cyclic adenosine monophosphate-mediated signaling in immediate early responsive gene X-1-deficient vascular smooth muscle cells. Hypertension. 2010; 56(4):705-12.

15. Kim E, Tolhurst AT, Qin LY, Chen XY, Febbraio M, Cho S. CD36/fatty acid translocase, an inflammatory mediator, is involved in hyperlipidemia-induced exacerbation in ischemic brain injury. J Neurosci. 2008; 28(18):4661-70.

16. Fu ZH, Wang JH, Sun JH, Chen XY, Xu JG. Fu’s subcutaneous needling-Possible clinical evidence of the subcutaneous connective tissue in acupuncture. J Altern Complement Med. 2007;13(1):47-51

17. Chen XY, Zhang W, Zhang W, Wu S, Bi F, Su YJ, Tan XY, Liu JN, Zhang J. Vaccination with viable HUVECs prevents metastatic tumors by attack on tumor vasculature with both cellular and humoral immunity. Clin Cancer Res. 2006; 12(19):5834-5840.

18. Fu ZH, Chen XY, Lu LJ, Lin J, Xu JG. Immediate effect of Fu’s Subcutaneous Needling for Low Back Pain. Chin Med J. 2006, 119(11): 953-956.

19. Ding BS, Zhou YJ, Chen XY, Zhang J, Zhang PX, Sun ZY, Tan XY, and Liu JN. Lung Endothelium Targeting for Pulmonary Embolism Thrombolysis. Circulation. 2003; 108:2892-2898.

Books

20. Chen X, Wu MX. Laser for skin vaccine delivery and adjuvantation. Molecular Vaccines – from Prophylaxis to Therapy, Springer International Publishing, Book Chapter, 2014/1/1, 519-525

 

发布时间:2015/05/20
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